Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level

Ezrin is a key regulator of cancer metastasis that links the extracellular matrix to the actin cytoskeleton and regulates cell morphology and motility. We discovered a small-molecule inhibitor, NSC305787, that directly binds to ezrin and inhibits its function. In this study, we used a nano-liquid ch...

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Publié dans:Mol Cell Biol
Auteurs principaux: Çelik, Haydar, Sajwan, Kamal P., Selvanathan, Saravana P., Marsh, Benjamin J., Pai, Amrita V., Kont, Yasemin Saygideger, Han, Jenny, Minas, Tsion Z., Rahim, Said, Erkizan, Hayriye Verda, Toretsky, Jeffrey A., Üren, Aykut
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539380/
https://ncbi.nlm.nih.gov/pubmed/26149384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00332-15
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