Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling

The disruption of normal hematopoiesis has been observed in leukemia, but the mechanism is unclear. Osteoblasts originate from bone mesenchymal stem cells (BMSCs) and can maintain normal hematopoiesis. To investigate how leukemic cells inhibit the osteogenic differentiation of BMSCs and the role of...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Yang, Gui-Cun, Xu, You-Hua, Chen, Hong-Xia, Wang, Xiao-Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539167/
https://ncbi.nlm.nih.gov/pubmed/26339248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/162410
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