Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks of cancer, including tumor proliferation, invasion and metastasis, inflammation, angiogenesis, and escape of immune survei...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Herbertz, Stephan, Sawyer, J Scott, Stauber, Anja J, Gueorguieva, Ivelina, Driscoll, Kyla E, Estrem, Shawn T, Cleverly, Ann L, Desaiah, Durisala, Guba, Susan C, Benhadji, Karim A, Slapak, Christopher A, Lahn, Michael M
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2015
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539082/
https://ncbi.nlm.nih.gov/pubmed/26309397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S86621
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