Reconstitution of TCA cycle with DAOCS to engineer Escherichia coli into an efficient whole cell catalyst of penicillin G

Many medically useful semisynthetic cephalosporins are derived from 7-aminodeacetoxycephalosporanic acid (7-ADCA), which has been traditionally made by the polluting chemical method. Here, a whole-cell biocatalytic process based on an engineered Escherichia coli strain expressing 2-oxoglutarate–depe...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lin, Baixue, Fan, Keqiang, Zhao, Jian, Ji, Junjie, Wu, Linjun, Yang, Keqian, Tao, Yong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538657/
https://ncbi.nlm.nih.gov/pubmed/26216972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502866112
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