Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Although targeting cancer metabolism is a promising therapeutic strategy, clinical success will depend on an accurate diagnostic identification of tumor subtypes with specific metabolic requirements. Through broad metabolite profiling, we successfully identified three highly distinct metabolic subty...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Daemen, Anneleen, Peterson, David, Sahu, Nisebita, McCord, Ron, Du, Xiangnan, Liu, Bonnie, Kowanetz, Katarzyna, Hong, Rebecca, Moffat, John, Gao, Min, Boudreau, Aaron, Mroue, Rana, Corson, Laura, O’Brien, Thomas, Qing, Jing, Sampath, Deepak, Merchant, Mark, Yauch, Robert, Manning, Gerard, Settleman, Jeffrey, Hatzivassiliou, Georgia, Evangelista, Marie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538616/
https://ncbi.nlm.nih.gov/pubmed/26216984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501605112
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