Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

One reported mechanism for morphine activation of dopamine (DA) neurons of the ventral tegmental area (VTA) is the disinhibition model of VTA-DA neurons. Morphine inhibits GABA inhibitory neurons, which shifts the balance between inhibitory and excitatory input to VTA-DA neurons in favor of excitati...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chen, Ming, Zhao, Yanfang, Yang, Hualan, Luan, Wenjie, Song, Jiaojiao, Cui, Dongyang, Dong, Yi, Lai, Bin, Ma, Lan, Zheng, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538365/
https://ncbi.nlm.nih.gov/pubmed/26208338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09275
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