Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

One reported mechanism for morphine activation of dopamine (DA) neurons of the ventral tegmental area (VTA) is the disinhibition model of VTA-DA neurons. Morphine inhibits GABA inhibitory neurons, which shifts the balance between inhibitory and excitatory input to VTA-DA neurons in favor of excitati...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Chen, Ming, Zhao, Yanfang, Yang, Hualan, Luan, Wenjie, Song, Jiaojiao, Cui, Dongyang, Dong, Yi, Lai, Bin, Ma, Lan, Zheng, Ping
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2015
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538365/
https://ncbi.nlm.nih.gov/pubmed/26208338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09275
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