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Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice

RATIONALE: Extracellular-signal regulated protein kinase (ERK1/2) is activated by ethanol in reward-related brain regions. Accordingly, systemic inhibition of ERK1/2 potentiates ethanol reinforcement. However, the brain region(s) that mediate this effect are unknown. OBJECTIVE: To pharmacologically...

詳細記述

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書誌詳細
出版年:Psychopharmacology (Berl)
主要な著者: Faccidomo, Sara, Salling, Michael C, Galunas, Christina, Hodge, Clyde W
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537834/
https://ncbi.nlm.nih.gov/pubmed/26123321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-015-3993-z
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