Real Time Measurement of Hyperpolarized Lactate Production and Efflux as a Biomarker of Tumor Aggressiveness in an MR compatible 3D Cell Culture Bioreactor

We have developed a 3D cell/tissue culture bioreactor compatible with hyperpolarized (HP) (13)C MR and interrogated HP [1-(13)C] lactate production and efflux in human renal cell carcinoma (RCC) cells. This platform is capable of resolving intracellular and extracellular HP lactate pools, allowing t...

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Опубликовано в: :NMR Biomed
Главные авторы: Sriram, Renuka, Van Criekinge, Mark, Hansen, Ailin, Wang, Zhen J., Vigneron, Daniel B., Wilson, David M., Keshari, Kayvan R., Kurhanewicz, John
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537810/
https://ncbi.nlm.nih.gov/pubmed/26202449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3354
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