Arginine-Vasopressin Receptor Blocker Conivaptan Reduces Brain Edema and Blood-Brain Barrier Disruption after Experimental Stroke in Mice

BACKGROUND: Stroke is a major cause of morbidity and mortality. Stroke is complicated by brain edema and blood-brain barrier (BBB) disruption, and is often accompanied by increased release of arginine-vasopressin (AVP). AVP acts through V1a and V2 receptors to trigger hyponatremia, vasospasm, and pl...

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Udgivet i:PLoS One
Main Authors: Zeynalov, Emil, Jones, Susan M., Seo, Jeong-Woo, Snell, Lawrence D., Elliott, J. Paul
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537303/
https://ncbi.nlm.nih.gov/pubmed/26275173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136121
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