Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators

Parkinson’s disease (PD) is characterized by the presence of Lewy bodies and degeneration of dopaminergic neurons. 1-methyl-4-phenylpyridinium (MPP+), a metabolite of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Lewy body component α-synuclein activates glia in PD pathogenesis....

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Vydáno v:PLoS One
Hlavní autoři: Kempuraj, Duraisamy, Thangavel, Ramasamy, Yang, Evert, Pattani, Sagar, Zaheer, Smita, Santillan, Donna A., Santillan, Mark K., Zaheer, Asgar
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537263/
https://ncbi.nlm.nih.gov/pubmed/26275153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135776
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