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Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma

UV radiation induced genomic instability is one of the leading causes for melanoma. Phosphorylation of Ataxia Telangiectasia Mutated (ATM) is one of the initial events that follow DNA damage. Phospho-ATM (p-ATM) plays a key role in the activation of DNA repair and several oncogenic pathways as well...

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Udgivet i:PLoS One
Main Authors: Bhandaru, Madhuri, Martinka, Magdalena, McElwee, Kevin J., Rotte, Anand
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537129/
https://ncbi.nlm.nih.gov/pubmed/26275218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134678
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