miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1)

Cyclin E1, encoded by the CCNE1 gene, promotes G1/S transition, chromosome instability, and oncogenesis. Here, we show that miR-497 and miR-34a target the 3′-UTR of CCNE1. miR-497 and miR-34a are downregulated in cancer cells and their ectopic expression inhibited cell proliferation and colony forma...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Han, Zhiyuan, Zhang, Yanbin, Yang, Qiaoyuan, Liu, Binbin, Wu, Jianjun, Zhang, Yajie, Yang, Chengfeng, Jiang, Yiguo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537005/
https://ncbi.nlm.nih.gov/pubmed/25909221
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