PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes

Genome-wide association study (GWAS) data showed that the protein tyrosine phosphatase receptor type delta (PTPRD) is associated with increased susceptibility to type 2 diabetes (T2D) in Han Chinese. A replication study indicated that PTPRD is involved in the insulin signaling pathway; however, the...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Chen, Yng-Tay, Lin, Wei-De, Liao, Wen-Lin, Lin, Ying-Ju, Chang, Jan-Gowth, Tsai, Fuu-Jen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper: Gerotarget (Focus on Aging)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536994/
https://ncbi.nlm.nih.gov/pubmed/26079428
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