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IL-33 released by alum is responsible for early cytokine production and has adjuvant properties
Human vaccines have used aluminium-based adjuvants (alum) for >80 years despite incomplete understanding of how alum enhances the immune response. Alum can induce the release of endogenous danger signals via cellular necrosis which elicits inflammation-associated cytokines resulting in humoral im...
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| Published in: | Sci Rep |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536651/ https://ncbi.nlm.nih.gov/pubmed/26272855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13146 |
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