Staphylococcus aureus PerR Is a Hypersensitive Hydrogen Peroxide Sensor using Iron-mediated Histidine Oxidation

In many Gram-positive bacteria PerR is a major peroxide sensor whose repressor activity is dependent on a bound metal cofactor. The prototype for PerR sensors, the Bacillus subtilis PerR(BS) protein, represses target genes when bound to either Mn(2+) or Fe(2+) as corepressor, but only the Fe(2+)-bou...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ji, Chang-Jun, Kim, Jung-Hoon, Won, Young-Bin, Lee, Yeh-Eun, Choi, Tae-Woo, Ju, Shin-Yeong, Youn, Hwan, Helmann, John D., Lee, Jin-Won
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536443/
https://ncbi.nlm.nih.gov/pubmed/26134568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664961
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