Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells

Production of active TGF-β1 is one mechanism by which human regulatory T cells (Tregs) suppress immune responses. This production is regulated by glycoprotein A repetitions predominant (GARP), a transmembrane protein present on stimulated Tregs but not on other T lymphocytes (Th and CTLs). GARP form...

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Publicado en:J Biol Chem
Autores principales: Huygens, Caroline, Liénart, Stéphanie, Dedobbeleer, Olivier, Stockis, Julie, Gauthy, Emilie, Coulie, Pierre G., Lucas, Sophie
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536422/
https://ncbi.nlm.nih.gov/pubmed/26126825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655340
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