Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration.
Accumulation of the antiviral nucleoside analogue fialuridine (FIAU; 1-(2'-deoxy-2'-fluoro-beta-D-arab-inofuranosyl-5-iodouracil) in genomic DNA was examined with a modified version of a recently developed RIA for FIAU. DNA was obtained from tissues of dogs administered FIAU at 0, 1, 2, or 3 mg/kg o...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1994
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45364/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991573/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12003 |
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