Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine

BACKGROUND: Nitric oxide (NO) is known to play a key role in migraine pathogenesis, but modulation of NO synthesis has failed so far to show efficacy in migraine treatment. Asymmetric dimethylarginine (ADMA) is a NO synthase (NOS) inhibitor, whose levels are regulated by dimethylarginine dimethylami...

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Veröffentlicht in:J Headache Pain
Hauptverfasser: Greco, Rosaria, Ferrigno, Andrea, Demartini, Chiara, Zanaboni, Annamaria, Mangione, Antonina Stefania, Blandini, Fabio, Nappi, Giuseppe, Vairetti, Mariapia, Tassorelli, Cristina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Milan 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536246/
https://ncbi.nlm.nih.gov/pubmed/26272684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10194-015-0560-2
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