Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic- pituitary-adrenal axis activation

BACKGROUND: The development of ethanol dependence is associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis and activation of type II glucocorticoid receptors (GR). These effects may contribute to withdrawal-associated anxiety, craving and relapse to drinking. The present studies e...

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Veröffentlicht in:Drug Alcohol Depend
Hauptverfasser: Reynolds, Anna R., Saunders, Meredith A., Brewton, Honoree’ W., Winchester, Sydney R., Elgumati, Ibrahim S., Prendergast, Mark A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536150/
https://ncbi.nlm.nih.gov/pubmed/26143299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2015.06.018
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