Hox5 genes regulate the Wnt2/2b-Bmp4 signaling axis during lung development

Hox genes are required for proper anteroposterior axial patterning and the development of several organ systems. Herein, we show that all three Hox5 paralogous genes play redundant roles in the developing lung. Hoxa5;Hoxb5;Hoxc5 triple mutant embryos develop severely hypoplastic lungs with reduced b...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Hrycaj, Steven M., Dye, Briana R., Baker, Nicholas C., Larsen, Brian M., Burke, Ann C., Spence, Jason R., Wellik, Deneen M.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536095/
https://ncbi.nlm.nih.gov/pubmed/26235626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.020
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