Cloning of a human gene involved in cytochrome oxidase assembly by functional complementation of an oxa1- mutation in Saccharomyces cerevisiae.

The yeast nuclear gene OXA1 is essential for cytochrome oxidase assembly, so that a null mutation in the OXA1 gene leads to complete respiratory deficiency. We have cloned by genetic selection a human OXA1 (OXA1Hs) cDNA that complements the respiratory defect of yeast oxa1 mutants. The deduced seque...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Bonnefoy, N, Kermorgant, M, Groudinsky, O, Minet, M, Slonimski, P P, Dujardin, G
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 1994
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991568/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.11978
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