Improving arteriovenous fistula patency: Transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation

Creation of an autologous arteriovenous fistula (AVF) for vascular access in haemodialysis is the modality of choice. However neointimal hyperplasia and loss of the luminal compartment result in AVF patency rates of ~ 60% at 12 months. The exact cause of neointimal hyperplasia in the AVF is poorly u...

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Veröffentlicht in:Vascul Pharmacol
Hauptverfasser: MacAskill, Mark G., Watson, David G., Ewart, Marie-Ann, Wadsworth, Roger, Jackson, Andrew, Aitken, Emma, MacKenzie, Graeme, Kingsmore, David, Currie, Susan, Coats, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534710/
https://ncbi.nlm.nih.gov/pubmed/25866325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vph.2015.02.012
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