The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis

A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear. Using gene targeting to engineer a single-amino-acid mutation, w...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Vlachogiannis, Georgios, Niederhuth, Chad E., Tuna, Salih, Stathopoulou, Athanasia, Viiri, Keijo, de Rooij, Dirk G., Jenner, Richard G., Schmitz, Robert J., Ooi, Steen K.T.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534369/
https://ncbi.nlm.nih.gov/pubmed/25683717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.021
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