Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet

AMP-activated protein kinase (AMPK) plays an important role in insulin resistance, which is characterized by the impairment of the insulin-Akt signaling pathway. However, the time course of the decrease in AMPK and Akt phosphorylation in the liver during the development of obesity and insulin resist...

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Veröffentlicht in:PLoS One
Hauptverfasser: Shiwa, Mami, Yoneda, Masayasu, Okubo, Hirofumi, Ohno, Haruya, Kobuke, Kazuhiro, Monzen, Yuko, Kishimoto, Rui, Nakatsu, Yusuke, Asano, Tomoichiro, Kohno, Nobuoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534138/
https://ncbi.nlm.nih.gov/pubmed/26266809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135554
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