Estrogen sulfotransferase ablation sensitizes mice to sepsis

Sepsis is the host's deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the estrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response. Both the cecal ligation and puncture...

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Publicat a:Nat Commun
Autors principals: Chai, Xiaojuan, Guo, Yan, Jiang, Mengxi, Hu, Bingfang, Li, Zhigang, Fan, Jie, Deng, Meihong, Billiar, Timothy R., Kucera, Heidi, Gaikwad, Nilesh W., Xu, Meishu, Lu, Peipei, Yan, Jiong, Fu, Haiyan, Liu, Youhua, Yu, Lushan, Huang, Min, Zeng, Su, Xie, Wen
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532951/
https://ncbi.nlm.nih.gov/pubmed/26259151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8979
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