Estrogen sulfotransferase ablation sensitizes mice to sepsis

Sepsis is the host's deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the estrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response. Both the cecal ligation and puncture...

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書誌詳細
出版年:Nat Commun
主要な著者: Chai, Xiaojuan, Guo, Yan, Jiang, Mengxi, Hu, Bingfang, Li, Zhigang, Fan, Jie, Deng, Meihong, Billiar, Timothy R., Kucera, Heidi, Gaikwad, Nilesh W., Xu, Meishu, Lu, Peipei, Yan, Jiong, Fu, Haiyan, Liu, Youhua, Yu, Lushan, Huang, Min, Zeng, Su, Xie, Wen
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532951/
https://ncbi.nlm.nih.gov/pubmed/26259151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8979
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