Estrogen sulfotransferase ablation sensitizes mice to sepsis

Sepsis is the host's deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the estrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response. Both the cecal ligation and puncture...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Chai, Xiaojuan, Guo, Yan, Jiang, Mengxi, Hu, Bingfang, Li, Zhigang, Fan, Jie, Deng, Meihong, Billiar, Timothy R., Kucera, Heidi, Gaikwad, Nilesh W., Xu, Meishu, Lu, Peipei, Yan, Jiong, Fu, Haiyan, Liu, Youhua, Yu, Lushan, Huang, Min, Zeng, Su, Xie, Wen
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532951/
https://ncbi.nlm.nih.gov/pubmed/26259151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8979
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