Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells

Ectopic expression of Pdx1 triggers rapid hepatocyte dedifferentiation by down-regulating liver-enriched transcription factors and liver-specific functional genes such as hepatic nuclear factor-1α (HNF1α), albumin, and AAT. However, the links between Pdx1 over-expression and hepatic gene down-regula...

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Bibliografiska uppgifter
I publikationen:Am J Transl Res
Huvudupphovsmän: Donelan, William, Li, Shiwu, Wang, Hai, Lu, Shun, Xie, Chao, Tang, Dongqi, Chang, Lung-Ji, Yang, Li-Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: e-Century Publishing Corporation 2015
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532734/
https://ncbi.nlm.nih.gov/pubmed/26279745
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