Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation

The removal of histone H3 trimethylation at lysine residue 27 (H3K27me3) plays a critical role in the transcriptional initiation of developmental genes. The H3K27me3-specific KDM6 demethylases JMJD3 and UTX are responsible for the transcriptional initiation of various developmental genes, but some g...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kang, Sung Chul, Kim, Se Kye, Chai, Jin Choul, Kim, Sun Hwa, Won, Kyoung-Jae, Lee, Young Seek, Jung, Kyoung Hwa, Chai, Young Gyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532468/
https://ncbi.nlm.nih.gov/pubmed/26263556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135276
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