Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation.

In the presence of emetine, an inhibitor of protein synthesis, nascent DNA on forward arms of replication forks in hamster cell lines containing either single or amplified copies of the DHFR gene region was enriched 5- to 7-fold over nascent DNA on retrograde arms. This forward arm bias was observed...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Burhans, W C, Vassilev, L T, Wu, J, Sogo, J M, Nallaseth, F S, DePamphilis, M L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1991
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC453188/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1721870/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb05013.x
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