The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors.

Míreanna Comhchosúla

• Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.
  le: Woodcock, J M, et al.
  Foilsithe: (1994)
• Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.
  le: Sakamaki, K, et al.
  Foilsithe: (1992)
• Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.
  le: Hayashida, K, et al.
  Foilsithe: (1990)
• Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor.
  le: Kitamura, T, et al.
  Foilsithe: (1991)
• Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.
  le: Kinoshita, T, et al.
  Foilsithe: (1995)