CYP3A5 genotyping for assessing the efficacy of treatment with simvastatin and atorvastatin

In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who received 10-40 mg of atorvastatin (n = 175) or simva...

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Vydáno v:Genet Mol Biol
Hlavní autoři: Kolovou, Genovefa, Kolovou, Vana, Ragia, Georgia, Mihas, Constantinos, Diakoumakou, Olga, Vasiliadis, Ioannis, Mavrogeni, Sophie, Vartela, Vassiliki, Manolopoulos, Vangelis G
Médium: Artigo
Jazyk:Inglês
Vydáno: Sociedade Brasileira de Genética 2015
Témata:
Human and Medical Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530653/
https://ncbi.nlm.nih.gov/pubmed/26273214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1415-4757382220140239
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