Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

There is increasing evidence for disturbances within the glutamate system in patients with affective disorders, which involve disruptions of the glutamate–glutamine-cycle. The mainly astroglia-located enzyme glutamine synthetase (GS) catalyzes the ATP-dependent condensation of ammonia and glutamate...

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Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Bernstein, Hans-Gert, Meyer-Lotz, Gabriela, Dobrowolny, Henrik, Bannier, Jana, Steiner, Johann, Walter, Martin, Bogerts, Bernhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530620/
https://ncbi.nlm.nih.gov/pubmed/26321908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00273
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