Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter syst...

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Publicat a:Cell Rep
Autors principals: Monfort, Asun, Di Minin, Giulio, Postlmayr, Andreas, Freimann, Remo, Arieti, Fabiana, Thore, Stéphane, Wutz, Anton
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2015
Matèries:
Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530576/
https://ncbi.nlm.nih.gov/pubmed/26190100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.067
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