Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction

Excessive production of cytokines by microglia may cause cognitive dysfunction and long-lasting behavioral changes. Activating the peripheral innate immune system stimulates cytokine secretion in the central nervous system, which modulates cognitive function. Histone deacetylases (HDACs) modulate cy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mediators Inflamm
Hauptverfasser: Hsing, Chung-Hsi, Hung, Shih-Kai, Chen, Yeong-Chang, Wei, Tsui-Shan, Sun, Ding-Ping, Wang, Jhi-Joung, Yeh, Ching-Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530275/
https://ncbi.nlm.nih.gov/pubmed/26273133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/163140
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