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Managing Side Effects of Vemurafenib Therapy for Advanced Melanoma
Somatic point mutations in the BRAF gene have been found in approximately 50% of melanomas. BRAF(V600E), the most common mutation, results in the constitutive activation of BRAF(V600E) kinase, sustaining MAPK signaling and perpetuating cell growth. This groundbreaking discovery led to the clinical d...
Uloženo v:
| Vydáno v: | J Adv Pract Oncol |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Harborside Press
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530112/ https://ncbi.nlm.nih.gov/pubmed/26328215 |
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