Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease

BACKGROUND: The chemokine interleukin-8 (IL-8) and its receptor CXCR2 contribute to chemotactic responses in Alzheimer’s disease (AD); however, properties of the ligand and receptor have not been characterized in animal models of disease. The primary aim of our study was to examine effects of pharma...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Ryu, Jae K, Cho, T, Choi, Hyun B, Jantaratnotai, N, McLarnon, James G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529987/
https://ncbi.nlm.nih.gov/pubmed/26255110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0339-z
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