Evidence for a single-niche model of positive selection.
Thymocyte maturation depends on interactions with thymic stromal elements expressing major histocompatibility complex (MHC) molecules. Mutant mouse strains lacking MHC class I (beta 2-microglobulin-null) or class II (A beta-null) expression fail to generate normal CD8 or CD4 T-cell populations and p...
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| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1994
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45298/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972126/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.24.11694 |
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