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PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease
Poly (ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that is involved in physiological processes as DNA repair, genomic stability, and apoptosis. Moreover, published studies demonstrated that PARP-1 mediates necrotic cell death in response to excessive DNA damage under certain pathological co...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4529170/ https://ncbi.nlm.nih.gov/pubmed/26252217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134482 |
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