A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

Metabolic adaptation is considered an emerging hallmark of cancer, whereby cancer cells exhibit high rates of glucose consumption with consequent lactate production. To ensure rapid efflux of lactate, most cancer cells express high levels of monocarboxylate transporters (MCTs), which therefore may c...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Pertega‐Gomes, Nelma, Felisbino, Sergio, Massie, Charlie E, Vizcaino, Jose R, Coelho, Ricardo, Sandi, Chiranjeevi, Simoes‐Sousa, Susana, Jurmeister, Sarah, Ramos‐Montoya, Antonio, Asim, Mohammad, Tran, Maxine, Oliveira, Elsa, Lobo da Cunha, Alexandre, Maximo, Valdemar, Baltazar, Fatima, Neal, David E, Fryer, Lee GD
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528232/
https://ncbi.nlm.nih.gov/pubmed/25875424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4547
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