SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes its interacting partner protein LRPPRC by protecting it from degradation. Although SLIRP is completely dependent on LRPPRC for its stability, reduced levels of LRPPRC...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Lagouge, Marie, Mourier, Arnaud, Lee, Hyun Ju, Spåhr, Henrik, Wai, Timothy, Kukat, Christian, Silva Ramos, Eduardo, Motori, Elisa, Busch, Jakob D., Siira, Stefan, Kremmer, Elisabeth, Filipovska, Aleksandra, Larsson, Nils-Göran
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527767/
https://ncbi.nlm.nih.gov/pubmed/26247782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005423
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