Early ART After Cryptococcal Meningitis Is Associated With Cerebrospinal Fluid Pleocytosis and Macrophage Activation in a Multisite Randomized Trial

Introduction. Earlier antiretroviral therapy (ART) initiation in cryptococcal meningitis resulted in higher mortality compared with deferred ART initiation (1–2 weeks vs 5 weeks postmeningitis diagnosis). We hypothesized this was due to ART-associated immune pathology, without clinically recognized...

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Pubblicato in:J Infect Dis
Autori principali: Scriven, James E., Rhein, Joshua, Hullsiek, Katherine Huppler, von Hohenberg, Maximilian, Linder, Grace, Rolfes, Melissa A., Williams, Darlisha A., Taseera, Kabanda, Meya, David B., Meintjes, Graeme, Boulware, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527410/
https://ncbi.nlm.nih.gov/pubmed/25651842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv067
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