Effects of different interchain linkers on biological activity of an anti-prostate cancer single-chain bispecific antibody

BACKGROUND: A single-chain bispecific antibody (scBsAb; an engineered antibody), has promising clinical applications. Nonetheless, the effect of different interchain linkers on its activity is poorly understood. METHODS: Gene synthesis was used to splice the anti-γ-seminoprotein single-chain antibod...

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Detalhes bibliográficos
Publicado no:Theor Biol Med Model
Main Authors: Hao, Chao-hui, Han, Qian-he, Shan, Zhong-jie, Hu, Jian-ting, Zhang, Nan, Zhang, Xue-pei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527239/
https://ncbi.nlm.nih.gov/pubmed/26246000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12976-015-0010-5
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