Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis.

In order to define the active site(s) of human tumour necrosis factor (hTNF), we mutagenized its gene at random and directly screened the resulting population for loss of cytotoxic activity on L929 cells. Four biologically inactive mutant proteins (Arg32----Trp, Leu36----Phe, Ser86----Phe and Ala84-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Van Ostade, X, Tavernier, J, Prangé, T, Fiers, W
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 1991
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452723/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2009860/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb08015.x
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak