MicroRNA-101 is repressed by EZH2 and its restoration inhibits tumorigenic features in embryonal rhabdomyosarcoma

BACKGROUND: Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 histone H3 methyltransferase that regulates the balance between cell proliferation...

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Bibliographic Details
Published in:Clin Epigenetics
Main Authors: Vella, Serena, Pomella, Silvia, Leoncini, Pier Paolo, Colletti, Marta, Conti, Beatrice, Marquez, Victor E., Strillacci, Antonio, Roma, Josep, Gallego, Soledad, Milano, Giuseppe M., Capogrossi, Maurizio C., Bertaina, Alice, Ciarapica, Roberta, Rota, Rossella
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527101/
https://ncbi.nlm.nih.gov/pubmed/26251675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0107-z
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