Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

Plasma membrane targeting of p21K-ras(B) requires a CAAX motif and a polybasic domain. The CAAX box directs a triplet of post-translational modifications: farnesylation, proteolysis of the AAX amino acids and methylesterification. These modifications are closely coupled in vivo. However, in vitro tr...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Hancock, J F, Cadwallader, K, Marshall, C J
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 1991
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452695/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2001678/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb07992.x
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