Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways

Avian reovirus (ARV) protein p17 has been shown to regulate cell cycle and autophagy by activation of p53/PTEN pathway; nevertheless, it is still unclear how p53 and PTEN are activated by p17. Here, we report for the first time that p17 functions as a nucleoporin Tpr suppressor that leads to p53 nuc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Huang, Wei-Ru, Chiu, Hung-Chuan, Liao, Tsai-Ling, Chuang, Kuo-Pin, Shih, Wing-Ling, Liu, Hung-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526660/
https://ncbi.nlm.nih.gov/pubmed/26244501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133699
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