Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)

Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating pre-mRNA splicing events through the extensive phosphorylation of splicing factors from the family...

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Udgivet i:PLoS One
Main Authors: Siqueira, Raoni Pais, Barbosa, Éverton de Almeida Alves, Polêto, Marcelo Depólo, Righetto, Germanna Lima, Seraphim, Thiago Vargas, Salgado, Rafael Locatelli, Ferreira, Joana Gasperazzo, Barros, Marcus Vinícius de Andrade, de Oliveira, Leandro Licursi, Laranjeira, Angelo Brunelli Albertoni, Almeida, Márcia Rogéria, Júnior, Abelardo Silva, Fietto, Juliana Lopes Rangel, Kobarg, Jörg, de Oliveira, Eduardo Basílio, Teixeira, Robson Ricardo, Borges, Júlio César, Yunes, Jose Andrés, Bressan, Gustavo Costa
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526641/
https://ncbi.nlm.nih.gov/pubmed/26244849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134882
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