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Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway
PURPOSE: To study composition and heterogeneity of insoluble subvisible particles in Mab formulations resulting from degradation of polysorbate 20 and to develop a better understanding of the mechanisms of polysorbate degradation leading to particle formation. METHODS: In this study, we exploit the...
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| Publicat a: | Pharm Res |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer US
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526581/ https://ncbi.nlm.nih.gov/pubmed/25773722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1670-x |
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