Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile

Evidence from systems biology indicates that promiscuous drugs, i.e. those that act simultaneously at various protein targets, are clinically better in terms of efficacy, than those that act in a more selective fashion. This has generated a new trend in drug development called polypharmacology. Howe...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Möller-Acuña, Patricia, Contreras-Riquelme, J. Sebastián, Rojas-Fuentes, Cecilia, Nuñez-Vivanco, Gabriel, Alzate-Morales, Jans, Iturriaga-Vásquez, Patricio, Arias, Hugo R., Reyes-Parada, Miguel
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526571/
https://ncbi.nlm.nih.gov/pubmed/26244344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134444
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