Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile

Evidence from systems biology indicates that promiscuous drugs, i.e. those that act simultaneously at various protein targets, are clinically better in terms of efficacy, than those that act in a more selective fashion. This has generated a new trend in drug development called polypharmacology. Howe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Möller-Acuña, Patricia, Contreras-Riquelme, J. Sebastián, Rojas-Fuentes, Cecilia, Nuñez-Vivanco, Gabriel, Alzate-Morales, Jans, Iturriaga-Vásquez, Patricio, Arias, Hugo R., Reyes-Parada, Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526571/
https://ncbi.nlm.nih.gov/pubmed/26244344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134444
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