Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells

Autophagy is a vital pathway for the removal of β-amyloid peptide (Aβ) and the aggregated proteins that cause Alzheimer’s disease (AD). We previously found that cilostazol induced SIRT1 expression and its activity in neuronal cells, and thus, we hypothesized that cilostazol might stimulate clearance...

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Vydáno v:PLoS One
Hlavní autoři: Lee, Hye Rin, Shin, Hwa Kyoung, Park, So Youn, Kim, Hye Young, Bae, Sun Sik, Lee, Won Suk, Rhim, Byung Yong, Hong, Ki Whan, Kim, Chi Dae
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526537/
https://ncbi.nlm.nih.gov/pubmed/26244661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134486
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