Elucidation of the aggregation pathways of helix-turn-helix peptides: Stabilization at the turn region is critical for fibril formation

Aggregation of proteins to fiber-like aggregates often involves a transformation of native monomers to β-sheet-rich oligomers. This general observation underestimates the importance of α-helical segments in the aggregation cascade. Here, using a combination of experimental techniques and accelerated...

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Udgivet i:Biochemistry
Main Authors: Do, Thanh D., Chamas, Ali, Zheng, Xueyun, Barnes, Aaron, Chang, Dayna, Veldstra, Tjitske, Takhar, Harmeet, Dressler, Nicolette, Trapp, Benjamin, Miller, Kylie, McMahon, Audrene, Meredith, Stephen C., Shea, Joan-Emma, Cantrell, Kristi Lazar, Bowers, Michael T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526104/
https://ncbi.nlm.nih.gov/pubmed/26070092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00414
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